Specific chromosomal aberrations in polycythemia vera

Chromosomal aberrations in polycythemia vera.

By B. MODAN, B. PADEH, H. KALLNER, E. Axsr IN, D. MEYTES, P. CZERNIAK, B. RAMOT, J. PINKHAS AND M. MODAN T HE RELATIVELY HICH RISK of developing leukemia in the course of polycythemia vera ( PV ) , and the presence of both specific and nonspecific chromosomal aberrations in patients with myeloprohferative disorders,25 led us to undertake a prospective follow-up study of patients with PV. In thi...

Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b

Fifty-one polycythemia vera (PV) patients were enrolled in the phase I/II clinical study PEGINVERA to receive a new formulation of pegylated interferon alpha (peg-proline-IFNα-2b, AOP2014/P1101). Peg-proline-IFNα-2b treatment led to high response rates on both hematologic and molecular levels. Hematologic and molecular responses were achieved for 46 and 18 patients (90 and 35% of the whole coho...

Muramidase in polycythemia vera.

Ethnic-specific chromosomal aberrations in NSCLC

Purpose: East-Asian (EA) patients with Non Small Cell Lung Cancer (NSCLC) are associated with a high proportion of non-smoking women, EGFR activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We sought to identify novel molecular differences between EA and Western European (WE) NSCLCs. Experimental Design: 226 EA (90) and WE (136) lung adenocarcinomas were analyze...

Erythropoietin receptors in polycythemia vera.

The role of erythropoietin (EP) in polycythemia vera (PV) is controversial, with some experiments suggesting that erythroid progenitors in PV are exquisitely sensitive to EP and EP dependent, and others suggesting that PV progenitors are EP independent. We have examined the characteristics of the EP receptor (EP-R) on erythroid colony-forming cells (ECFC) from patients with PV. In contrast to n...